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Academic Article
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HIV-1 infection induces a selective reduction in STAT5 protein expression.
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Academic Article
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Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
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Academic Article
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JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
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Academic Article
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Selective disruption of interleukin 4 autocrine-regulated loop by a tyrosine kinase inhibitor restricts activity of T-helper 2 cells.
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Academic Article
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Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
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Academic Article
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Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
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Academic Article
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Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment.
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Academic Article
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Activation of receptor-associated tyrosine kinase JAK2 by prolactin.
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Academic Article
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Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.
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Academic Article
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Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.
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Academic Article
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The prohibitin protein complex promotes mitochondrial stabilization and cell survival in hematologic malignancies.
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Academic Article
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Prolactin activates Ras via signaling proteins SHC, growth factor receptor bound 2, and son of sevenless.
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Academic Article
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Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha.
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Academic Article
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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
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Academic Article
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Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase.
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Academic Article
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Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.
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Academic Article
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Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models.
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Academic Article
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Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
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Academic Article
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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
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Academic Article
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Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.
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Academic Article
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Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein.
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Academic Article
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Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
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Academic Article
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Targeting Jak3 for immune suppression and allograft acceptance.
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Academic Article
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PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection.
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Academic Article
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The role of Stat5 in the induction of regulatory T cells in transplantation tolerance.
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Academic Article
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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
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Academic Article
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Molecular actions of sirolimus: sirolimus and mTor.
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Academic Article
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Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function.
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Academic Article
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The role of IL-2 in allograft rejection--a lesson learned from experimental work.
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Academic Article
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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
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Academic Article
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Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
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Academic Article
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Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals.
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Academic Article
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Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.
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Academic Article
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Regulation of lymphoid cell apoptosis by Jaks and Stats.
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Academic Article
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Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit.
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Academic Article
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Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
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Academic Article
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The Mannich base NC1153 promotes long-term allograft survival and spares the recipient from multiple toxicities.
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Academic Article
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Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells.
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Academic Article
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Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance.
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Academic Article
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Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction.
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Academic Article
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JAK2 activation and cell proliferation induced by antibody-mediated prolactin receptor dimerization.
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Academic Article
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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
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Academic Article
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Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors.
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Academic Article
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Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
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Academic Article
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Regulation of T cell homeostasis by JAKs and STATs.
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Academic Article
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Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.
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Academic Article
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Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
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Academic Article
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STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
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Academic Article
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Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells.
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Academic Article
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Nitric oxide and thiol redox regulation of Janus kinase activity.
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Concept
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Protein Binding
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Concept
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Protein Conformation
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Concept
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Protein Kinases
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Concept
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Protein Processing, Post-Translational
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Concept
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Protein-Tyrosine Kinases
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Concept
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Protein Biosynthesis
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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Concept
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Mitogen-Activated Protein Kinase 1
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Concept
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Protein Isoforms
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Concept
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Receptor Protein-Tyrosine Kinases
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Concept
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Mitogen-Activated Protein Kinases
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Concept
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Protein Subunits
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Concept
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Protein Transport
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Concept
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Protein Sorting Signals
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Concept
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Protein Interaction Mapping
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Concept
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Protein Kinase Inhibitors
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Concept
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JNK Mitogen-Activated Protein Kinases
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Concept
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Mitogen-Activated Protein Kinase 3
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Concept
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bcl-X Protein
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Concept
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GRB2 Adaptor Protein
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Concept
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ZAP-70 Protein-Tyrosine Kinase
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Concept
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Protein Phosphatase 1
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Concept
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Protein Phosphatase 2
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Academic Article
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Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family.
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Academic Article
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High yield purification of a four subunit caa3-type cytochrome oxidase from the thermophilic bacterium Bacillus PS3 using fast protein liquid chromatography.
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Academic Article
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The Genomic Landscape of a Restricted ALL Cohort from Patients Residing on the U.S./Mexico Border.
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Academic Article
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Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
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Academic Article
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JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
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